![]() Chronic inflammation increases the acute phase proteins in human bodies (eg: C-reactive protein, serum amyloid, complement C3, fibrinogen, ceruloplasmin et.al.). An increased level of globulin has been proved to be related to chronic inflammation 6 - 8. ![]() Therefore, it plays an important role in immunity. It is known as immunoglobulin or antibody and secreted by B cells of the adaptive immune system. Among them, gamma globulin accounts for the largest proportion. Globulin family has several members including alpha, beta, and gamma globulins. Lower albumin levels indicated poor nutrition status which had been reported to predict poor survival in various type of cancers in the previous studies 1 - 5. Besides, it also involves in various sorts of physiological activities of human bodies. Moreover, they also bind cations, fatty acids, bilirubin, hormones and pharmaceuticals and act like the transporters. Albumins reflect the nutrition status of the human body, which are functioning as the regulators of colloid osmotic pressure of blood. According to the cut-off values, subgroup analysis showed that AGR had significant prognostic effect on OS in each cut-off intervals (≤1.20, 1.20-1.40 and ≥1.40).Ĭonclusion: Pre-treatment AGR is an effective prognostic factor and high AGR represents an ideal clinical outcome in the solid tumor patients.Īlbumins and globulin are the main components of serum proteins. Result: A total of 13890 solid tumor patients in 24 studies were included. The time-to-event outcomes were summarized in hazard ratio (HR) and 95% confidence interval (CI). The primary outcome was overall survival (OS) and the secondary outcomes were cancer-specific survival (CSS), disease-free survival (DFS) and disease-metastasis-free survival (DMFS). Method: Six electronic database were searched for the relevant articles that assessing the prognostic value of pre-treatment AGR in solid tumor patients. We therefore performed a meta-analysis to elucidate the prognosis effect of AGR on survival outcomes in solid tumors. Albumin-to-globulin ratio (AGR) has been reported as a prognostic factor in various cancers. ![]() The level of albumin and globulin partially represents the nutrition status and immune system. Malnutrition.Background: Albumin and globulin are main components of serum protein. Associations of aerobic and strength exercise with clinical laboratory test values. Total protein and albumin/globulin (A/G) ratio.įragala MS, Bi C, Chaump M, Kaufman HW, Kroll MH. Total Protein, Albumin-Globulin (A/G) Ratio. Elsevier Health Sciences 2017:382.Īmerican Association for Clinical Chemistry (AACC). Mosby’s Manual of Diagnostic and Laboratory Tests - E-Book. Baltimore, MD: Lippincott Williams & Wilkins 2007:341-342. Protein Electrophoresis - Serum Information. Can I Take Medication Before Having A Blood Test? Nhs.uk. Are patients well informed about the fasting requirements for laboratory blood testing?. Smart Bio-Impedance-Based Sensor for Guiding Standard Needle Insertion. Kudashov I, Shchukin S, Al-Harosh M, Shcherbachev A.
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